Deciphering the mechanisms underlying LRP-mediated axon guidance

破译 LRP 介导的轴突引导的机制

• 批准号: nhmrc : 1068317
• 负责人: A/Pr Lisa Foa
• 金额: $ 24.72万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-mechanisms-underlying-axon-guidance/455339
• 关键词: Deciphering; mechanisms; underlying; LRP; mediated

Nerve damage can develop post injury or disease and are often very debilitating, slow to heal and cause increased pain. Our work aims to examine a new class of molecules that we show can activate selected fat-receptors on nerve cells to guide the growth of regenerating nerves. We will determine how these receptors function with the aim of developing a novel class of therapeutics directed at healing nerve damage.

神经损伤可以在受伤或疾病后发展，并且通常非常虚弱，愈合缓慢并导致疼痛增加。我们的工作旨在研究一类新的分子，我们发现它们可以激活神经细胞上选定的脂肪受体，以指导再生神经的生长。我们将确定这些受体如何发挥作用，目的是开发一类新的治疗方法，用于治疗神经损伤。