Properties and Electro-Physiology of the Intrinsic Nervous System

内在神经系统的特性和电生理学

• 批准号: nhmrc : 114103
• 负责人: Prof Joel Bornstein
• 金额: $ 27.95万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/properties-electro-physiology-intrinsic-nervous/76153
• 关键词: Properties; Electro; Physiology; Intrinsic; Nervous

The gut contains a very large number of nerve cells which fall into several functionally distinct groups. We have identified virtually all these functional groups in the guinea-pig small intestine and have begun an analysis of the ways the different groups communicate with each other. We have developed methods to identify the functions of any nerve cell from which we record and have also developed novel methods for specifically stimulating individual functional classes of nerve cells that contact them. The aim of the proposed research is to exploit these methods to identify the chemicals used by specifc types of nerve cell in transmission of information to other nerve cells during the normal behaviour of the intestine. We will record the behaviour of individual nerve cells in the gut wall while stimulating specific nerve pathways that contact them. We will then use drugs that block the activity of the chemicals of interest (small proteins called tachykinins, and certain amine compounds) to try and block the transmission of information between the nerve cells involved. Identification of the nature of the chemicals used at specific connections between different functional groups of nerve cells in the gut will allow the design of drugs for treatment of gastrointestinal disorders that will have minimal side effects. Further because the chemicals that are used for communication in the gut are also found in the brain, the results will provide evidence about the functions of these chemicals elsewhere in the nervous system.

肠道含有大量的神经细胞，这些细胞可分为几个功能不同的组。我们已经确定了豚鼠小肠中几乎所有这些功能群，并开始分析不同群体相互沟通的方式。我们已经开发了方法来识别我们记录的任何神经细胞的功能，也开发了新的方法来特异性地刺激与它们接触的神经细胞的单个功能类别。拟议研究的目的是利用这些方法来识别特定类型的神经细胞在肠道正常行为期间向其他神经细胞传递信息时使用的化学物质。我们将记录肠壁中单个神经细胞的行为，同时刺激与它们联系的特定神经通路。然后，我们将使用药物来阻止感兴趣的化学物质（称为速激肽的小蛋白质和某些胺化合物）的活性，试图阻止相关神经细胞之间的信息传递。确定肠道中不同功能神经细胞群之间的特定连接所使用的化学物质的性质，将有助于设计出副作用最小的治疗胃肠道疾病的药物。此外，由于肠道中用于交流的化学物质也存在于大脑中，因此研究结果将为这些化学物质在神经系统其他部位的功能提供证据。