Protective role of the depressor arm of the renin-angiotensin system during pregnancy

揭示与妊娠相关的异常血管舒张中所涉及的正常激素和分子机制的动机是，了解这些基本过程可能会为先兆子痫和宫内生长受限的病理生理学提供新的见解，以及不仅治疗这些妊娠特异性疾病而且治疗非妊娠女性和男性心血管和肾脏疾病的潜在治疗策略。

The motivation for unveiling the normal hormonal and molecular mechanisms involved in the extraordinary vasodilatation associated with pregnancy is that understanding these fundamental processes may provide novel insights into the pathophysiology of preeclampsia and intrauterine growth restriction, as well as potential therapeutic strategies for not only the treatment of these pregnancy specific conditions but also cardiovascular and renal diseases in non-pregnant women and men.