Role of epigenomic changes in conferring hyperglycemic memory

表观基因组变化在赋予高血糖记忆中的作用

• 批准号: nhmrc : 1048377
• 负责人: Dr Christos Tikellis
• 金额: $ 42.42万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-epigenomic-changes-hyperglycemic-memory/112015
• 关键词: Role; epigenomic; changes; conferring; hyperglycemic

The major burden of type I diabetes remains its vascular complications including diabetes-accelerated athersclerosis. Despite improved glucose control, diabetic individuals develop complications as a result of prior poor glycemic control. Although the development and progression of these diabetic complications is strongly associated with mean levels of glucose, recent studies suggest that the deleterious effects of early exposure to high levels of glucose persist for years even after treatment has returned glucose levels towards normal.

I型糖尿病的主要负担仍然是其血管并发症，包括糖尿病加速的动脉粥样硬化。尽管血糖控制有所改善，但糖尿病患者会因先前血糖控制不佳而出现并发症。虽然这些糖尿病并发症的发展和进展与平均血糖水平密切相关，但最近的研究表明，即使在治疗使血糖水平恢复正常后，早期暴露在高血糖水平下的有害影响仍会持续多年。