Characterising and exploiting δ subunit-containing GABA-A receptors as novel targets for treating social disorders

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Our recent pilot data provides the first solid evidence that δGABAARs are involved in social behaviour and we have effectively targeted them pharmacologically to reduce social deficits in a rodent autism model. This project will: (1) thoroughly define the role of δ-GABAARs in social behaviour; (2) assess abnormal functioning of δ-GABAARs in a rodent model of autism; and (3) discover and develop new drugs targeting δ-GABAARs, potentially providing much needed drug candidates for social disorders.