An Integrated Genomic and Epigenomic Approach to Dissect the Aetiology of Motor Neuron Disease

运动神经元病(MND)是一种神经疾病，它破坏控制肌肉活动的运动神经元，如行走。它影响40岁的人，大多数患者在3年内死亡。目前还没有针对其诊断的特定测试，也没有治愈的方法。我的目标是建立一个独立的研究小组，发现新的基因和表观遗传标记，并剖析它们在MND中的生物学功能。这些知识对于寻找有效的诊断、治疗和治愈MND是至关重要的。

Motor neuron disease (MND) is a neurological disease that destroys motor neurons, which control muscle activity, such as walking. It affects people >40 years old and most patients die within 3 years. There is no specific test for its diagnosis and there are no cures. I aim to build an independent research group to discover novel genes and epigenetic marks, and to dissect their biological function in MND. This knowledge is crucial for finding effective diagnosis, treatment and cure for MND.