A -induced cell death signalling by the p75 neurotrophin receptor.

A - 由 p75 神经营养蛋白受体诱导的细胞死亡信号传导。

• 批准号: nhmrc : 569507
• 负责人: Prof Elizabeth Coulson
• 金额: $ 36.43万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/induced-cell-death-neurotrophin-receptor/81368
• 关键词: induced; cell; death; signalling; p75

The amyloid peptide A is central to the cause of Alzheimer's disease. We have recently found that A can activate the cell death receptor p75NTR which is found in the nerve cells that die in Alzheimer's disease. This project will study whether this death pathway underpins the neuronal death associated with Alzheimer's disease. It will also determine the mechanism by which A activates p75NTR death signalling, and identify biochemical ways to prevent this from occurring.

淀粉样蛋白A是阿尔茨海默病的中心病因。我们最近发现，A可以激活细胞死亡受体p75NTR，该受体存在于阿尔茨海默病死亡的神经细胞中。该项目将研究这一死亡途径是否支持与阿尔茨海默病相关的神经元死亡。它还将确定A激活p75NTR死亡信号的机制，并确定防止这种情况发生的生化方法。