Molecular mechanisms of neuronal survival

神经元存活的分子机制

• 批准号: nhmrc : 569601
• 负责人: Prof Elizabeth Coulson
• 金额: $ 28.58万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-neuronal-survival/116116
• 关键词: Molecular; mechanisms; neuronal; survival

Nerve cell survival is dependent on both growth-promoting factors and factors released by neurotransmission, which can promote recovery in neurodegenerative conditions by overriding cell death pathways. The molecule responsible for activating death pathways in the nervous system is called p75. This project will investigate how p75 results in cell death, how synaptic signals can prevent the activation of the p75 death pathway and whether blocking p75 function can limit neurodegeneration.

神经细胞的存活依赖于生长促进因子和神经传递释放的因子，这些因子可以通过覆盖细胞死亡途径来促进神经退行性疾病的恢复。负责激活神经系统中死亡途径的分子被称为p75。该项目将研究p75如何导致细胞死亡，突触信号如何阻止p75死亡途径的激活以及阻断p75功能是否可以限制神经退行性变。