Regulation of p75 death signalling: How neurotransmitter- and neurotrophic- signals determine cell survival

p75 死亡信号传导的调节：神经递质和神经营养信号如何决定细胞存活

• 批准号: nhmrc : 511107
• 负责人: Prof Elizabeth Coulson
• 金额: $ 19.49万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-p75-death-cell-survival/99862
• 关键词: Regulation; p75; death; signalling; How

Nerve cell survival is dependent on trophic support in the form of growth factors and synaptic input, both of which promote recovery after nerve injury. The survival pathways activated by growth factors are generally well characterised, whereas survival signals activated by synaptic activity are largely unexplored. This proposal aims to discover how synaptic activity prevents nerve cell death by looking at how synaptic activity inhibits the processes active in dying nerve cells.

神经细胞的存活依赖于生长因子和突触输入形式的营养支持，这两者都促进神经损伤后的恢复。由生长因子激活的存活途径通常被很好地表征，而由突触活性激活的存活信号在很大程度上未被探索。这项提案旨在通过观察突触活动如何抑制垂死神经细胞中活跃的过程来发现突触活动如何防止神经细胞死亡。