Regulation of p75 death signalling: How neurotransmitter- and neurotrophic- signals determine cell survival

神经细胞的存活依赖于生长因子和突触输入形式的营养支持，两者都促进神经损伤后的恢复。由生长因子激活的生存途径通常被很好地描述，而由突触活动激活的生存信号在很大程度上是未知的。本提案旨在通过观察突触活动如何抑制濒死神经细胞中活跃的过程来发现突触活动如何阻止神经细胞死亡。

Nerve cell survival is dependent on trophic support in the form of growth factors and synaptic input, both of which promote recovery after nerve injury. The survival pathways activated by growth factors are generally well characterised, whereas survival signals activated by synaptic activity are largely unexplored. This proposal aims to discover how synaptic activity prevents nerve cell death by looking at how synaptic activity inhibits the processes active in dying nerve cells.