Randomised controlled trial of intravenous antivenom versus placebo in the treatment of redback spider bite

静脉注射抗蛇毒血清与安慰剂治疗赤背蜘蛛咬伤的随机对照试验

• 批准号: nhmrc : 545228
• 负责人: Prof Geoffrey Isbister
• 金额: $ 32.5万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/randomised-controlled-trial-spider-bite/100795
• 关键词: Randomised; controlled; trial; intravenous; antivenom

Redback spiderbite is the most common significant envenoming in Australia and bites by the closely related widow spiders are a major global problem. Despite widespread use of redback spider antivenom, no controlled study has tested its effectiveness. This study aims to test the efficacy of antivenom versus placebo in a large multicentre, randomised controlled trial - RAVE-II. It is of critical importance to determine if an expensive treatment with a known risk of allergic reactions is effective.

红背蜘蛛咬伤是澳大利亚最常见的重大envenoming和叮咬密切相关的寡妇蜘蛛是一个重大的全球性问题。尽管红背蜘蛛抗蛇毒血清被广泛使用，但没有对照研究测试其有效性。本研究的目的是在一项大型多中心随机对照试验- RAVE-II中测试抗蛇毒血清与安慰剂的疗效。至关重要的是，要确定一个昂贵的治疗与已知的过敏反应的风险是有效的。