Red cell disorders and the regulation of iron homeostasis

红细胞疾病和铁稳态的调节

• 批准号: nhmrc : 613688
• 负责人: Dr David Frazer
• 金额: $ 40.35万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/red-cell-disorders-iron-homeostasis/100435
• 关键词: Red; cell; disorders; regulation; iron

Iron is an essential nutrient, but it is also toxic when present in excess, so the amount of iron moving into and around the body must be tightly controlled. In this project we will investigate how this body iron movement is regulated, and in particular the role played by macrophages, the cells that clean up old red blood cells. An understanding of this process will be of great benefit in the analysis and treatment of important blood diseases and disorders of iron metabolism.

铁是一种必需的营养素，但过量存在时也是有毒的，因此必须严格控制铁进入和进入身体周围的量。在这个项目中，我们将研究这种身体铁运动是如何调节的，特别是巨噬细胞所起的作用，巨噬细胞是清理旧红细胞的细胞。对这一过程的理解将对分析和治疗重要的血液疾病和铁代谢紊乱大有裨益。