The role of soluble transferrin receptor in the regulation of iron homeostasis

可溶性转铁蛋白受体在铁稳态调节中的作用

• 批准号: nhmrc : 1051764
• 负责人: Dr David Frazer
• 金额: $ 35.98万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-soluble-transferrin-iron-homeostasis/112236
• 关键词: role; soluble; transferrin; receptor; regulation

Iron is both essential for health and toxic in excess so the body very tightly regulates how much iron is absorbed from the diet. One of the most important regulators of dietary iron absorption is the iron demands of developing red blood cells. In this project we will investigate how developing red blood cells signal changes in iron absorption. An understanding of this process will be of great benefit in the analysis and treatment of important blood diseases and disorders of iron metabolism.

铁对健康至关重要，过量则有毒，因此身体非常严格地调节从饮食中吸收多少铁。膳食铁吸收的最重要的调节器之一是发育中的红细胞的铁需求。在这个项目中，我们将研究如何发展中的红细胞信号的变化，铁的吸收。对这一过程的理解将对分析和治疗重要的血液疾病和铁代谢紊乱大有裨益。