An investigation into the role of 3’UTR dynamics in breast cancer metastasis

3-UTR 动力学在乳腺癌转移中作用的研究

• 批准号: nhmrc : GNT1128250
• 负责人: A/Pr David Powell
• 金额: $ 62.74万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-investigation-role-cancer-metastasis/1347676
• 关键词: investigation; into; role; UTR; dynamics

Basic research has brought many improvements to the diagnosis and treatment of cancer. An exception are the triple negative breast cancers. No targeted therapies yet exist, and thus a combination of chemotherapy, surgery and radiation therapy is the only option. For 2/3rds of women this works well and survivor rates are high, but the prognosis is poor for those that do not respond. This research aims to reveal therapeutic opportunities to block the potential of such tumours to spread.

基础研究为癌症的诊断和治疗带来了许多进步。三阴性乳腺癌是一个例外。目前还没有针对性的治疗方法，因此化疗、手术和放射治疗的结合是唯一的选择。对于三分之二的女性来说，这种方法效果很好，生存率很高，但对于那些没有反应的女性来说，预后很差。这项研究旨在揭示阻止此类肿瘤扩散的治疗机会。