Analysis and regulation of leptospiral virulence factors.

钩端螺旋体毒力因子分析与调控。

• 批准号: nhmrc : 545826
• 负责人: Prof Ben Adler
• 金额: $ 42.04万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-regulation-leptospiral-virulence-factors/99408
• 关键词: Analysis; regulation; leptospiral; virulence; factors.

Leptospirosis is a globally important infectious disease caused by Leptospira spp. This project aims to identify and characterise factors which play a role in disease development by knocking out genes, then investigating the impact on overall gene-protein expression in the mutant strain and its ability to cause disease. This will allow us to gain insights on mechanisms by which Leptospira spp. cause disease, leading to development of better methods of disease control and prevention.

钩端螺旋体病是由钩端螺旋体属引起的全球性重要传染病。该项目旨在通过敲除基因来识别和消除在疾病发展中发挥作用的因素，然后研究突变株对整体基因蛋白表达的影响及其致病能力。这将使我们能够深入了解钩端螺旋体的机制。导致疾病，导致更好的疾病控制和预防方法的发展。