The Bcl-2 life/death switch - Why do some Bcl-2 proteins kill cells whilst others promote their survival?

Bcl-2 生/死开关 - 为什么一些 Bcl-2 蛋白能杀死细胞，而另一些却能促进细胞存活？

• 批准号: nhmrc : 1008329
• 负责人: Dr Walter Fairlie
• 金额: $ 25.04万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bcl-2-lifedeath-promote-survival/109304
• 关键词: Bcl; life; death; switch; Why

The cells of all animals possess the ability to commit suicide. When this natural process of cell death is dysfunctional, diseases such as cancer arise. Our aim is to understand the molecular mechanisms that underlie this process by providing atomic resolution snapshots of key components of the cell death machinery. By understanding the fine details of cell death regulation we can develop new drugs that target and kill rogue cells such as those found in tumours.

所有动物的细胞都具有自杀的能力。当这种细胞死亡的自然过程功能失调时，就会出现癌症等疾病。我们的目标是通过提供细胞死亡机制关键组成部分的原子分辨率快照来了解这一过程的分子机制。通过了解细胞死亡调控的细节，我们可以开发新的药物，靶向和杀死流氓细胞，如那些在肿瘤中发现的。