Selective targeting of apoptotic pathways for therapy

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The cells of all animals possess the ability to commit suicide. When this natural process of cell death is dysfunctional, diseases such as cancer arise. New anti-cancer drugs aimed at targeting key components of the cell death machinery are showing promise in some patients, but not all. Our aim is to determine whether targeting other cell death components could be a more effective approach. We will also develop new chemicals that could one day allow such strategies to be applied in the clinic.