The structure - function relationship of NCC27, a novel nuclear chloride ion channel protein

新型核氯离子通道蛋白NCC27的结构-功能关系

• 批准号: nhmrc : 157059
• 负责人: Dr Walter Fairlie
• 金额: $ 16.11万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-function-relationship-channel-protein/98941
• 关键词: structure; function; relationship; NCC27; novel

Ion channels (IC) are complex proteins that regulate the transport of salts, an essential cell function. We have recently cloned a new IC, NCC27, unique in its location on the nuclear membrane, a site where they were previously thought to be unnecessary. The function of nuclear membrane ICs is unknown but our studies suggest that NCC27 is involved in regulating cell division. Because NCC27 has unique functional and structural characteristics, it will be particularly useful for answering fundamental questions relevant to the biology of animal cells: the role of nuclear membrane ICs in cell division; the way the structure of NCC27 allows it to carry out its function.

离子通道（IC）是一种复杂的蛋白质，调节盐的运输，是细胞的基本功能。我们最近克隆了一个新的IC， NCC27，它在核膜上的位置是独一无二的，在这个位置上它们以前被认为是不必要的。核膜ic的功能尚不清楚，但我们的研究表明NCC27参与调节细胞分裂。由于NCC27具有独特的功能和结构特征，它将特别有助于回答与动物细胞生物学相关的基本问题：核膜ic在细胞分裂中的作用；NCC27的结构方式允许它执行其功能。