The biology & therapeutic manipulation of Lymphatic vessels in cancer & lymphedema

生物学

• 批准号: nhmrc : 280900
• 负责人: Prof Marc Achen
• 金额: $ 172.64万
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biology-therapeutic-manipulation-cancer-lymphedema/96869
• 关键词: biology; therapeutic; manipulation; Lymphatic; vessels

This proposal brings together a team of researchers from diverse backgrounds who have already made important discoveries about the molecular control of the lymphatic system in normal physiology and cancer. The lymphatic vasculature consists of a network of vessels in organs and tissues that is critical for the regulation of tissue fluid volume and immune function. The lymphatics are also important for the metastatic spread of cancer, as they provide a route by which tumour cells spread to distant sites in the body, and for lymphedema, a condition in which lymphatic dysfunction leads to swelling of tissues. This program will explore the molecular mechanisms that control the growth and differentiation of the lymphatic vessels. It will greatly enhance our understanding of lymphatic vessel growth (lymphangiogenesis) and generate a range of reagents for stimulating or inhibiting this process. These reagents will be tested in animal models for their capacity to modulate lymphatic function in the context of cancer and lymphedema.

该提案汇集了一个来自不同背景的研究人员团队，他们已经在正常生理学和癌症中对淋巴系统的分子控制做出了重要发现。淋巴管系统由器官和组织中的血管网络组成，对于组织液体积和免疫功能的调节至关重要。淋巴系统对于癌症的转移性扩散也很重要，因为它们提供了肿瘤细胞扩散到体内远端部位的途径，并且对于水肿也很重要，这是一种淋巴功能障碍导致组织肿胀的病症。该计划将探索控制淋巴管生长和分化的分子机制。它将极大地增强我们对淋巴管生长（淋巴管生成）的理解，并产生一系列刺激或抑制这一过程的试剂。将在动物模型中检测这些试剂在癌症和水肿背景下调节淋巴功能的能力。