Understanding the molecular pathways that determine response to anti-angiogenic therapy

了解决定抗血管生成治疗反应的分子途径

• 批准号: nhmrc : 1045518
• 负责人: Prof Marc Achen
• 金额: $ 13.97万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-molecular-pathways-angiogenic-therapy/111757
• 关键词: Understanding; molecular; pathways; determine; response

Anti-angiogenesis is an important new approach to treat conditions such as cancer and eye disease. Our study is designed to understand the molecular pathways that lead to patients either being or developing resistance to these treatments. Using advanced cell and molecular biology techniques we will identify ways in which the blood vessels evade these therapies. Once identified these molecules will provide additional targets for developing therapeutics and diagnostics.

抗血管生成是治疗癌症和眼病等疾病的重要新方法。我们的研究旨在了解导致患者对这些治疗产生或发展抵抗的分子途径。利用先进的细胞和分子生物学技术，我们将确定血管逃避这些治疗的方式。一旦确定，这些分子将为开发治疗学和诊断学提供额外的靶点。