The biophysical basis of HCN channels in human peripheral nerve

人体周围神经HCN通道的生物物理基础

• 批准号: nhmrc : 1038791
• 负责人: Dr James Howells
• 金额: $ 3.36万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biophysical-basis-hcn-peripheral-nerve/111215
• 关键词: biophysical; basis; HCN; channels; human

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role as pacemakers in the cardiac and nervous systems. HCN channel dysfunction is implicated in a number of disorders including neuropathic pain and epilepsy. My aim is to determine the kinetics and voltage dependence of HCN channels in human peripheral nerve in vivo. Understanding these channels is a prerequisite to the development of safe targeted therapies against neuropathic pain.

超极化激活的环核苷酸门控（HCN）通道在心脏和神经系统中起着重要的起搏作用。HCN通道功能障碍涉及许多疾病，包括神经性疼痛和癫痫。我的目的是确定动力学和电压依赖性的HCN通道在人体周围神经在体内。了解这些通道是开发安全的神经性疼痛靶向治疗的先决条件。