The contributions of different sources of calcium to the induction of long term potentiation
The contributions of different sources of calcium to the induction of long term potentiation
批准号:
nhmrc : 224248
负责人:
Prof Steve Redman
金额:
$17.85万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2003
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2003-01-01 至 2005-12-31
中文摘要
当我们产生记忆时,我们改变了神经细胞之间突触连接的强度。这些变化在海马体中尤为明显;脑区大脑中与记忆形成有关的区域如果突触连接的强度足以激活神经元,导致钙离子水平上升,那么突触连接的强度就会发生改变。钙可以从神经元内的几个来源获得。本项目旨在评估这些不同来源的钙在诱导突触强度增加中的相对重要性。
英文摘要
When we make memories, we alter the strength of synaptic connections between nerve cells.These changes are particularly marked in the hippopcampus ; a region of the brain involved in the formation of memories. The strength of a synaptic connection is altered if it activates a neurone sufficiently to cause a rise in the level of calcium ions. Calcium can be derived from several sources within the neurone. This project aims to assess the relative importance of these different sources of calcium in inducing increases in synaptic strength.
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