The contributions of different sources of calcium to the induction of long term potentiation

不同来源的钙对诱导长时程增强的贡献

• 批准号: nhmrc : 224248
• 负责人: Prof Steve Redman
• 金额: $ 17.85万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contributions-different-sources-term-potentiation/76431
• 关键词: contributions; different; sources; calcium; induction

When we make memories, we alter the strength of synaptic connections between nerve cells.These changes are particularly marked in the hippopcampus ; a region of the brain involved in the formation of memories. The strength of a synaptic connection is altered if it activates a neurone sufficiently to cause a rise in the level of calcium ions. Calcium can be derived from several sources within the neurone. This project aims to assess the relative importance of these different sources of calcium in inducing increases in synaptic strength.

当我们产生记忆时，我们会改变神经细胞之间突触连接的强度，这些变化在海马区尤为明显;海马区是大脑中与记忆形成有关的区域。如果突触连接充分激活神经元，导致钙离子水平升高，那么突触连接的强度就会改变。钙可以从神经元内的几个来源获得。本项目旨在评估这些不同来源的钙在诱导突触强度增加方面的相对重要性。