The development of store operated calcium channel monoclonal antibody inhibitors as a therapeutic option for breast cancer treatment

开发商店经营的钙通道单克隆抗体抑制剂作为乳腺癌治疗的选择

• 批准号: nhmrc : 1017311
• 负责人: Prof Gregory Monteith
• 金额: $ 15.39万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-store-operated-cancer-treatment/109850
• 关键词: development; store; operated; calcium; channel

Despite recent advances in the treatment of breast cancer, a significant proportion of women with this disease receive little benefit from currently available treatments and die from breast cancer. Hence, new therapies for the breast cancers with the poorest prognosis are needed. This grant exploits our earlier finding that a specific calcium channel is a likely therapeutic target for breast cancer. Funding from this grant will be used to develop an inhibitory monoclonal antibody to this target.

尽管最近在治疗乳腺癌方面取得了进展，但患有这种疾病的妇女中有很大一部分从目前可用的治疗中获益甚少，并死于乳腺癌。因此，需要针对预后最差的乳腺癌的新疗法。这项资助利用了我们早期的发现，即特定的钙通道可能是乳腺癌的治疗靶点。这笔赠款的资金将用于开发针对该目标的抑制性单克隆抗体。