The plasmalemmal calcium pump and vascular smooth muscle cell proliferation.

质膜钙泵和血管平滑肌细胞增殖。

• 批准号: nhmrc : 102426
• 负责人: Prof Gregory Monteith
• 金额: $ 11.98万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/plasmalemmal-calcium-pump-cell-proliferation/78177
• 关键词: plasmalemmal; calcium; pump; vascular; smooth

Excessive growth of smooth muscle cells can lead to adverse effects in our arteries. The level of calcium inside the muscle cells that line our arteries appears to regulate their growth. In these studies we will assess the changes in the synthesis (expression) of a pump which removes calcium from cells. We will also characterise the effects of modifiers of cell growth on the expression of the calcium pump. The effect of directly inhibiting the production of the calcium pump, on the growth of smooth muscle cells and the regulation of calcium will be determined for the first time.

平滑肌细胞的过度生长会对我们的动脉造成不良影响。排列在我们动脉上的肌肉细胞内的钙水平似乎调节着它们的生长。在这些研究中，我们将评估从细胞中去除钙的泵的合成（表达）的变化。我们还将研究细胞生长调节剂对钙泵表达的影响。将首次确定直接抑制钙泵产生对平滑肌细胞生长和钙调节的影响。