An active ion transport pathway exploited by coronaviruses

冠状病毒利用的活性离子传输途径

• 批准号: DP220101406
• 负责人: Prof Gregory Monteith
• 金额: $ 39.6万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101406
• 关键词: active; ion; transport; pathway; exploited

Cells have active transport “pumps” that are regulators of a variety of cellular processes. This project aims to understand how a specific ion pump is exploited by coronaviruses when they infect animal cells. These studies will provide new mechanistic insights into how coronaviruses alter calcium signalling in cells and how a specific ion pump regulates a variety of key processes during coronavirus infection. This work will greatly enhance our understanding of the intersection between ion pumps and viruses.

细胞有活跃的运输“泵”，是各种细胞过程的调节器。这个项目旨在了解当冠状病毒感染动物细胞时，特定的离子泵是如何被冠状病毒利用的。这些研究将为冠状病毒如何改变细胞内的钙信号以及特定的离子泵如何在冠状病毒感染期间调节各种关键过程提供新的机械性见解。这项工作将极大地提高我们对离子泵和病毒之间的交集的理解。