Exploiting the overexpression of a specific calcium permeable ion channel in breast cancer cells: a new pharmacological approach to targeting breast cancer.

利用乳腺癌细胞中特定钙渗透性离子通道的过度表达：一种针对乳腺癌的新药理学方法。

• 批准号: nhmrc : 1079671
• 负责人: Prof Gregory Monteith
• 金额: $ 38.52万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploiting-overexpression-specific-breast-cancer/518687
• 关键词: Exploiting; overexpression; specific; calcium; permeable

We have identified that a specific protein that controls the entry of calcium into cells is found at much higher levels in some breast cancer cells. We have also identified that drugs that control the activity of this protein can promote the death of some breast cancer cells. This grant will help further define the mechanism of this effect and determine the applicability of this approach as a therapy for some women with breast cancer.

我们已经发现一种控制钙进入细胞的特定蛋白质在一些乳腺癌细胞中含量更高。我们还发现，控制这种蛋白质活性的药物可以促进一些乳腺癌细胞的死亡。这笔拨款将有助于进一步确定这种效应的机制，并确定这种方法是否适用于某些乳腺癌妇女的治疗。