The distinctive roles of tissue transglutaminase isoforms in neuroblastoma

组织转谷氨酰胺酶亚型在神经母细胞瘤中的独特作用

• 批准号: nhmrc : 568753
• 负责人: A/Pr Tao Liu
• 金额: $ 20.78万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/distinctive-roles-tissue-isoforms-neuroblastoma/80769
• 关键词: distinctive; roles; tissue; transglutaminase; isoforms

Neuroblastoma is the commonest solid tumour in early childhood. Neuroblastoma caused by N-Myc oncogene accounts for about one third of the disease and represents a more aggressive subtype with a worse clinical outcome. This project aims to identify factors responsible for N-Myc-induced neuroblastoma initiation and factors sensitizing neuroblastoma cells to anti-cancer drugs, and to provide the basis for clinical trials of a combination therapy in children with neuroblastoma.

神经母细胞瘤是儿童早期最常见的实体瘤。由N-Myc癌基因引起的神经母细胞瘤约占疾病的三分之一，并且代表了具有更差临床结果的更具侵袭性的亚型。该项目旨在确定负责N-Myc诱导的神经母细胞瘤起始的因素和使神经母细胞瘤细胞对抗癌药物敏感的因素，并为儿童神经母细胞瘤联合治疗的临床试验提供基础。