Targeting JMJD6 gene gain for the therapy of neuroblastoma

靶向 JMJD6 基因增益治疗神经母细胞瘤

• 批准号: nhmrc : 1106790
• 负责人: A/Pr Tao Liu
• 金额: $ 26.12万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-jmjd6-gene-therapy-neuroblastoma/662934
• 关键词: Targeting; JMJD6; gene; gain; therapy

Cancer is the most common cause of death from disease in children. Neuroblastoma is the most prevalent solid tumour in early childhood. In this project, we will define the key role of JMJD6 gene gain in neuroblastoma cell proliferation, survival and tumourigenesis. We will also identify a novel therapeutic strategy for the treatment of neuroblastoma.

癌症是儿童疾病死亡的最常见原因。神经母细胞瘤是儿童早期最常见的实体瘤。在这个项目中，我们将确定 JMJD6 基因增益在神经母细胞瘤细胞增殖、存活和肿瘤发生中的关键作用。我们还将确定一种治疗神经母细胞瘤的新治疗策略。