Targeting Histone Deacetylases to Overcome Resistance of BRAFV600E Melanoma Cells to Apoptosis

靶向组蛋白脱乙酰酶克服 BRAFV600E 黑色素瘤细胞对细胞凋亡的抵抗

• 批准号: nhmrc : 1026458
• 负责人: A/Pr Tao Liu
• 金额: $ 23.55万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-histone-deacetylases-cells-apoptosis/110496
• 关键词: Targeting; Histone; Deacetylases; Overcome; Resistance

Results from early clinical studies with a new class of drugs in the treatment of melanoma have been very encouraging, but most tumors initially respond to the drugs regrow after short periods. We have recently shown that this is mainly related to resistance of melanoma cells to cell death induced by the drugs. In this project, we aim to explore a novel approach to overcome this resistance. If successful, the results will lead to new approaches in the treatment of melanoma.

用一种新的药物治疗黑色素瘤的早期临床研究结果非常令人鼓舞，但大多数肿瘤最初对药物有反应，在短期内重新生长。我们最近发现，这主要与黑色素瘤细胞对药物诱导的细胞死亡的抗性有关。在这个项目中，我们的目标是探索一种新的方法来克服这种阻力。如果成功的话，结果将导致黑色素瘤治疗的新方法。