The dual-edged sword of zinc as an innate immune antimicrobial weapon against uropathogenic E. coli
The dual-edged sword of zinc as an innate immune antimicrobial weapon against uropathogenic E. coli
批准号:
nhmrc : GNT1144967
负责人:
Prof Mark Schembri
金额:
$78.44万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --
中文摘要
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英文摘要
Infectious diseases are a major global health threat, and urinary tract infections (UTI) are one of the most common infectious diseases. Most UTI are caused by uropathogenic E. coli (UPEC). In order to cause infections, UPEC must be able to overcome our body’s first line of defence, the innate immune system. This project seeks to understand how our innate immune system uses zinc to combat bacterial infections, and how UPEC is able to defend against such responses in order to cause disease.
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