The dual-edged sword of zinc as an innate immune antimicrobial weapon against uropathogenic E. coli

锌的双刃剑作为对抗尿路致病性大肠杆菌的先天免疫抗菌武器

• 批准号: nhmrc : GNT1144967
• 负责人: Prof Mark Schembri
• 金额: $ 78.44万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dual-edged-sword-e-coli/1348652
• 关键词: dual; edged; sword; zinc; innate

Infectious diseases are a major global health threat, and urinary tract infections (UTI) are one of the most common infectious diseases. Most UTI are caused by uropathogenic E. coli (UPEC). In order to cause infections, UPEC must be able to overcome our body’s first line of defence, the innate immune system. This project seeks to understand how our innate immune system uses zinc to combat bacterial infections, and how UPEC is able to defend against such responses in order to cause disease.

感染性疾病是全球主要的健康威胁，而尿路感染（UTI）是最常见的感染性疾病之一。大多数尿路感染是由尿路致病性大肠杆菌引起的。大肠杆菌（UPEC）。为了引起感染，UPEC必须能够克服我们身体的第一道防线，先天免疫系统。该项目旨在了解我们的先天免疫系统如何使用锌来对抗细菌感染，以及UPEC如何能够防御这种反应以引起疾病。