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Role of autotransporter proteins in uropathogenic E. coli infections

Role of autotransporter proteins in uropathogenic E. coli infections
自转运蛋白在尿路致病性大肠杆菌感染中的作用
批准号:
nhmrc : 1042651
负责人:
Prof Mark Schembri
金额:
$40.75万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31

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中文摘要
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英文摘要
Urinary tract infections (UTI) are among the most common infectious diseases of humans. Uropathogenic E. coli (UPEC), the primary cause of UTI, utilize a range of adherence mechanisms to colonize the urinary tract. In this project we will characterise the function and mode of secretion for one important class of UPEC adherence factors – autotransporter proteins. This work may inform new approaches to prevent UTI, an urgent need given the rapid increase in resistance to antibiotics among UPEC.
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国内基金
海外基金
百日咳博德特氏菌血清抗性蛋白BrkA跨膜结构域的晶体学研究