Role of autotransporter proteins in uropathogenic E. coli infections

自转运蛋白在尿路致病性大肠杆菌感染中的作用

• 批准号: nhmrc : 1042651
• 负责人: Prof Mark Schembri
• 金额: $ 40.75万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-autotransporter-proteins-coli-infections/111504
• 关键词: Role; autotransporter; proteins; uropathogenic; E.

Urinary tract infections (UTI) are among the most common infectious diseases of humans. Uropathogenic E. coli (UPEC), the primary cause of UTI, utilize a range of adherence mechanisms to colonize the urinary tract. In this project we will characterise the function and mode of secretion for one important class of UPEC adherence factors – autotransporter proteins. This work may inform new approaches to prevent UTI, an urgent need given the rapid increase in resistance to antibiotics among UPEC.

尿路感染（UTI）是人类最常见的传染病之一。尿路致病性大肠杆菌（UPEC）是尿路感染的主要原因，它利用一系列粘附机制在尿路中定植。在这个项目中，我们将描述一类重要的UPEC粘附因子-自体转运蛋白的功能和分泌模式。这项工作可能为预防UTI的新方法提供信息，鉴于UPEC中抗生素耐药性的迅速增加，这是一项迫切需要。