The immunoregulatory domains and binding interactions of human respiratory syncytial virus non-structural proteins

人呼吸道合胞病毒非结构蛋白的免疫调节域和结合相互作用

• 批准号: nhmrc : 511020
• 负责人: A/Pr Kirsten Spann
• 金额: $ 32.28万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immunoregulatory-domains-binding-structural-proteins/98464
• 关键词: immunoregulatory; domains; binding; interactions; human

Human respiratory syncytial virus (HRSV) is the leading cause of lower respiratory tract disease in infants and yet there are no vaccines available. HRSV exacerbates disease by interfering with the innate immune response. We aim to establish the mechanism by which this occurs by identifying the cellular-viral protein interactions involved, and by identifying the specific regions of the viral proteins responsible. This information will allow targeted vaccines and antivirals to be developed.

人类呼吸道合胞病毒（HRSV）是婴儿下呼吸道疾病的主要原因，但目前尚无疫苗可用。 HRSV 通过干扰先天免疫​​反应来加剧疾病。我们的目标是通过识别所涉及的细胞-病毒蛋白相互作用以及识别负责的病毒蛋白的特定区域来建立发生这种情况的机制。这些信息将有助于开发有针对性的疫苗和抗病毒药物。