Antiviral defects of the airway epithelium associated with wheeze and atopy in children

与儿童喘息和特应性相关的气道上皮抗病毒缺陷

• 批准号: nhmrc : 1061921
• 负责人: A/Pr Kirsten Spann
• 金额: $ 43.91万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/antiviral-defects-airway-atopy-children/454943
• 关键词: Antiviral; defects; airway; epithelium; associated

Asthma affects 10-15% of Australian. Repeated respiratory viral infections increase the risk of developing asthma, and are also the principal cause of asthma attacks. Asthmatics may be more susceptible to respiratory viral infections due to a defect in the innate antiviral response to infection. Here we aim to identify defects in the antiviral response of children who are at risk of developing asthma, and understand how they occur so that future therapies may be developed.

哮喘影响10-15%的澳大利亚人。反复呼吸道病毒感染会增加患哮喘的风险，也是哮喘发作的主要原因。哮喘患者可能更容易受到呼吸道病毒感染，这是由于对感染的先天性抗病毒反应存在缺陷。在这里，我们的目标是确定有哮喘风险的儿童的抗病毒反应缺陷，并了解它们是如何发生的，以便将来可以开发治疗方法。