The male partner contribution to pregnancy immune tolerance deficit in women

男性伴侣对女性妊娠免疫耐受缺陷的影响

• 批准号: nhmrc : GNT1139509
• 负责人: Dr David Sharkey
• 金额: $ 146.29万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/male-partner-contribution-deficit-women/1348227
• 关键词: male; partner; contribution; pregnancy; immune

A complication-free pregnancy and birth of a healthy infant depends on adequate preparation of the mother's immune system to tolerate the 'foreign' fetus, Both the mother and the father contribute to establishing optimal immune tolerance. This project will determine the links between specific agents in male seminal fluid and the female immune response, and will make progress towards new diagnostic tests and treatment options for unexplained subfertility and gestational disorders.

无并发症的怀孕和健康婴儿的出生取决于母亲免疫系统的充分准备，以耐受“外来”胎儿，母亲和父亲都有助于建立最佳的免疫耐受性。该项目将确定男性精液中的特定物质与女性免疫反应之间的联系，并将在不明原因的生育力低下和妊娠期疾病的新诊断测试和治疗方案方面取得进展。