The mechanism by which apical-basal polarity complexes regulate the Salvador-Warts-Hippo pathway

顶端-基底极性复合物调节 Salvador-Warts-Hippo 通路的机制

• 批准号: nhmrc : 628401
• 负责人: A/Pr Helena Richardson
• 金额: $ 36.01万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-apical-basal-hippo-pathway/76720
• 关键词: mechanism; apical; basal; polarity; complexes

Cancer is a multi-hit process involving the activation of critical signaling pathways leading to increased proliferation, survival and increased invasion-metastasis. We have discovered that a neoplastic tumour suppressor gene, lgl, acts though the Salvador-Warts-Hippo (SWH) tumour suppressor pathway to inhibit cell proliferation and cell survival. Here we use the model organism, Drosophila, and mammalian epithelial cells to determine the mechanism by which Lgl activates the SWH pathway.

癌症是一个多点作用的过程，涉及关键信号通路的激活，导致增殖增加、生存增加和侵袭转移增加。我们已经发现，肿瘤抑制基因LGL通过萨尔瓦多-沃茨-河马(SWH)肿瘤抑制途径抑制细胞增殖和细胞生存。在这里，我们使用模式生物果蝇和哺乳动物上皮细胞来确定LGL激活SWH途径的机制。