The mechanism by which apical-basal polarity complexes regulate the Salvador-Warts-Hippo pathway
The mechanism by which apical-basal polarity complexes regulate the Salvador-Warts-Hippo pathway
批准号:
nhmrc : 628401
负责人:
A/Pr Helena Richardson
金额:
$36.01万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
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英文摘要
Cancer is a multi-hit process involving the activation of critical signaling pathways leading to increased proliferation, survival and increased invasion-metastasis. We have discovered that a neoplastic tumour suppressor gene, lgl, acts though the Salvador-Warts-Hippo (SWH) tumour suppressor pathway to inhibit cell proliferation and cell survival. Here we use the model organism, Drosophila, and mammalian epithelial cells to determine the mechanism by which Lgl activates the SWH pathway.
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国内基金
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