Identification of novel tumour suppressors in Ras-mediated tumourigenesis

Ras 介导的肿瘤发生中新型肿瘤抑制因子的鉴定

• 批准号: nhmrc : 1020525
• 负责人: A/Pr Helena Richardson
• 金额: $ 38.71万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-novel-tumour-mediated-tumourigenesis/110041
• 关键词: Identification; novel; tumour; suppressors; Ras

Cancer is a cooperative process, involving mutations in several genes. Activation of the signaling protein, Ras, contributes to ~30% of human cancers, but alone is not sufficient for tumour formation. The identification of cooperating Tumour Suppressors (TSs), and their analysis in the vinegar fly, Drosophila, mammalian cells and mouse models is key to understanding cancer progression and for the development of therapeutic regimes

癌症是一个合作过程，涉及几个基因的突变。信号蛋白Ras的激活导致约30%的人类癌症，但单独激活不足以形成肿瘤。在醋蝇、果蝇、哺乳动物细胞和小鼠模型中鉴定协同肿瘤抑制因子（TS）并对其进行分析是理解癌症进展和开发治疗方案的关键