The mechanism of HSV-1 transport in sensory axons and its unique assembly at the axon terminus

HSV-1在感觉轴突中的运输机制及其在轴突末端的独特组装

• 批准号: nhmrc : 1069193
• 负责人: Dr Monica Miranda Saksena
• 金额: $ 44.69万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-hsv-1-axon-terminus/455375
• 关键词: mechanism; HSV; transport; sensory; axons

Herpes simplex viruses 1 and 2 cause common diseases such as genital herpes and, occasionally, neonatal deaths and encephalitis and predisposes to HIV infection. New antiviral strategies are required for resistant viruses for control. These aims will be facilitated by understanding how HSV is transported down nerves and across into skin. In this study, we will define how a key viral protein plays a major role in assembly of the virus at the tip of the nerve before it enters skin.

单纯疱疹病毒1型和2型可引起生殖器疱疹等常见疾病，偶尔也会导致新生儿死亡和脑炎，并易感染艾滋病毒。需要新的抗病毒策略来控制耐药病毒。这些目标将通过了解HSV如何沿着神经运输并进入皮肤来实现。在这项研究中，我们将确定一个关键的病毒蛋白如何在病毒进入皮肤之前在神经尖端的组装中发挥重要作用。