Transport, assembly and egress of herpes simplex virus in neurones

单纯疱疹病毒在神经元中的运输、组装和排出

• 批准号: nhmrc : 570849
• 负责人: Dr Monica Miranda Saksena
• 金额: $ 42.65万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transport-assembly-egress-virus-neurones/78331
• 关键词: Transport; assembly; egress; herpes; simplex

Herpes simplex viruses 1 and 2 are important pathogens, causing encephalitis, blindness and severe neonatal infection but they also enhance the acquisition of HIV three-fold. The transport of the virus to and from the periphery to the spinal cord is a key component of their life cycle. Determination of the exact mechanism will assist in a general understanding of nerve function and the development of new strategies for antiviral drugs.

单纯疱疹病毒1型和2型是重要的病原体，可引起脑炎、失明和严重的新生儿感染，但它们也使艾滋病毒的感染增加三倍。病毒从外周到脊髓的运输是其生命周期的关键组成部分。确切机制的确定将有助于对神经功能的全面了解和抗病毒药物新策略的开发。