The mechanisms of the anabolic actions of androgens in bone.

骨中雄激素的合成代谢作用机制。

• 批准号: nhmrc : 566503
• 负责人: A/Pr Rachel Davey
• 金额: $ 31.4万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-anabolic-actions-androgens-bone/94891
• 关键词: mechanisms; anabolic; actions; androgens; bone.

Androgens (male sex hormones) are one of the few agents that increase bone formation. Androgens act by binding to a specific protein, the androgen receptor (AR). To understand exactly how androgens increase bone formation, we will study mice in which the AR is inactivated only in bone forming cells at specific stages of their development. Understanding the way in which androgens act on bone to increase size and strength will be of great benefit in the design of new treatments for osteoporosis.

雄激素（男性性激素）是为数不多的促进骨骼形成的因素之一。雄激素通过与雄激素受体（AR）结合而起作用。为了确切了解雄激素是如何促进骨形成的，我们将研究仅在骨形成细胞发育的特定阶段AR失活的小鼠。了解雄激素作用于骨骼以增加尺寸和强度的方式将对骨质疏松症新疗法的设计大有裨益。