The physiological relevance of calcitonin in osteoclast function

降钙素与破骨细胞功能的生理相关性

• 批准号: nhmrc : 208994
• 负责人: A/Pr Rachel Davey
• 金额: $ 29.18万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/physiological-relevance-calcitonin-osteoclast-function/97796
• 关键词: physiological; relevance; calcitonin; osteoclast; function

Throughout adult life, bone tissue is continuously remodelled. The two main processes involved in bone remodelling, are bone formation and bone breakdown. Bone formation is controlled by cells known as osteoblasts and bone breakdown is controlled by cells known as osteoclasts. Under normal circumstances these two processes are tightly coupled. Excessive breakdown of bone, causes these two processes to become unbalanced and results in bone loss. This is the basis of many bone diseases such as osteoporosis, a condition in which the bones become fragile and therefore more susceptible to fracture. 1 in 2 women and 1 in 5 men aged 70 years and older suffer from osteoporosis in Australia. Despite this, the mechanisms which control osteoclast breakdown of bone are not well understood. Our laboratory is interested in how hormones affect osteoclast action. We plan to examine the role of the hormone calcitonin, thought to be important inhibitor of osteoclastic bone breakdown. This will be achieved by studying transgenic mice in which the receptor for calcitonin is specifically removed from osteoclasts. This will allow us to precisely determine the role of calcitonin in osteoclast function. Current treatment for osteoporosis involves the administration of drugs which inhibit bone breakdown. This project will increase our understanding of how calcitonin acts to regulate the function of osteoclasts. We believe that this research is of great importance as osteoporosis is becoming more prevalent as the population ages.

在整个成年生活中，骨组织不断重塑。骨重建的两个主要过程是骨形成和骨分解。骨的形成是由成骨细胞控制的，而骨的分解是由破骨细胞控制的。在正常情况下，这两个过程是紧密耦合的。骨的过度分解，导致这两个过程变得不平衡，导致骨丢失。这是许多骨骼疾病的基础，如骨质疏松症，骨骼变得脆弱，因此更容易骨折。在澳大利亚，70岁及以上的女性中有1/2，男性中有1/5患有骨质疏松症。尽管如此，控制破骨细胞分解骨的机制还没有很好地理解。我们实验室对激素如何影响破骨细胞的作用感兴趣。我们计划研究降钙素激素的作用，它被认为是骨细胞骨分解的重要抑制剂。这将通过研究转基因小鼠来实现，在转基因小鼠中，降钙素的受体被特异性地从破骨细胞中去除。这将使我们能够精确地确定降钙素在破骨细胞功能中的作用。目前对骨质疏松症的治疗包括施用抑制骨分解的药物。该项目将增加我们对降钙素如何调节破骨细胞功能的了解。我们认为，这项研究是非常重要的，因为骨质疏松症正变得越来越普遍，随着人口老龄化。