Role of non-classical actions of androgens in musculoskeletal physiology

雄激素(男性荷尔蒙)对肌肉和骨骼的生长维持很重要。雄激素的经典作用是与雄激素受体(AR)结合，调节靶基因。它们也可以通过其他细胞途径通过非经典的AR机制发挥作用。为了了解非经典作用在肌肉骨骼系统中的作用，我们将研究雄激素只能通过这一途径起作用的小鼠。这些知识对于治疗骨质疏松症和肌肉萎缩很重要。

Androgens (male sex hormones) are important for growth-maintenance of muscle and bone. The classical action of androgens is to bind the androgen receptor (AR) and regulate target genes. They can also act via non-classical AR mechanisms through other cellular pathways. To understand the role of non-classical actions in the musculoskeletal system we will study mice in which androgens can only act via this pathway. This knowledge is important for the treatment of osteoporosis and muscle wasting.