Role of non-classical actions of androgens in musculoskeletal physiology

雄激素非经典作用在肌肉骨骼生理学中的作用

• 批准号: nhmrc : 509328
• 负责人: A/Pr Rachel Davey
• 金额: $ 46.92万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-non-classical-musculoskeletal-physiology/82570
• 关键词: Role; non; classical; actions; androgens

Androgens (male sex hormones) are important for growth-maintenance of muscle and bone. The classical action of androgens is to bind the androgen receptor (AR) and regulate target genes. They can also act via non-classical AR mechanisms through other cellular pathways. To understand the role of non-classical actions in the musculoskeletal system we will study mice in which androgens can only act via this pathway. This knowledge is important for the treatment of osteoporosis and muscle wasting.

雄激素（雄性激素）对肌肉和骨骼的生长维持很重要。雄激素的经典作用是结合雄激素受体（AR）并调节靶基因。它们也可以通过其他细胞途径通过非经典AR机制发挥作用。为了了解非经典作用在肌肉骨骼系统中的作用，我们将研究雄激素只能通过这一途径发挥作用的小鼠。这些知识对于骨质疏松症和肌肉萎缩的治疗很重要。