Antithrombotic effect of NTPDase1/CD39

心脏病和中风的患病率在富裕的世界中正在增加。这些疾病是由于凝块形成导致动脉狭窄，从而减少了心脏和大脑的血液供应。血管闭塞是由于血小板凝集引发的凝块形成和血管壁周围的炎症的组合。防止血小板在血管内壁上聚集的药物在预防和治疗心脏病发作和中风方面发挥着重要作用。目前可用的药物不是普遍有效的，它们的使用往往受到不良反应的限制。在这篇论文中，我们建议研究一种新药的有效性，这种药物可以防止凝块形成，也可以解决炎症。这种药物是一种酶的衍生物，这种酶已经存在于血小板和血管细胞中。我们已经对这种酶进行了修饰，以增加血小板表面和血管壁细胞上的酶活性。我们将通过在实验室进行实验以及研究其在小鼠中的作用来彻底研究这种新药。

The prevalence of heart disease and stroke is increasing in the affluent world. These disorders are due to a narrowing of arteries due to clot formation, thereby reducing available blood supply to the heart and brain. Blood vessel occlusion is due a combination of clot formation initiated by platelet clumping, and inflammation surrounding the vessel wall. Drugs that prevent the clumping of platelets on the inner lining of the blood vessels play an important role in the prevention and treatment of heart attack and stroke. The currently available drugs are not universally effective and their use is often limited by adverse reactions. In this submission, we propose to investigate the efficiency of a new drug that will prevent clot formation and will also tackle inflammation. This drug is a derivative of an enzyme that is already present on platelets and cells that line blood vessels. We have modified this enzyme in a manner that will increase the enzyme activity on the surface of platelets and on the cells that line the blood vessel wall. We will thoroughly study this new drug by performing experiments in the laboratory as well as by studying its effect in mice.