A unique model of inflammatory bowel disease.

炎症性肠病的独特模型。

• 批准号: nhmrc : 114401
• 负责人: Prof Anthony D'Apice
• 金额: $ 23.51万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unique-model-inflammatory-bowel-disease/97441
• 关键词: unique; model; inflammatory; bowel; disease.

Inflammatory Bowel Disease (IBD) has two clinical forms known as Ulcerative Colitis (UC) and Crohn's Disease (CD). These are severe diseases which predominantly affect young people. They are occasionally fatal and often severely debilitating. Treatment of UC frequently requires removal of the large bowel and life long wearing of an ileostomy bag. While this is curative, its psychological and life style effects are very disturbing particularly in the young. The cause of IBD is unknown, although it is clear that there are both genetic and environmental factors. We have developed a model of IBD in mice which appears to be very like human UC. We have generated genetically modified mice in which it appears that the mucous secreted by their bowel wall is different from normal. We propose to investigate how this change leads to UC. It appears likely that the mucous is defective and can not prevent some of the normal bacteria or other material present in the stools from entering the bowel wall and causing chronic inflammation. If we can show that this is the case, it adds strong support to the the idea that a similar genetic trait may occur in some humans and that this may be one of the genetic components which renders them susceptible to IBD. Put another way, it would be a pointer to the type of genetic defect which may underlie susceptibility in humans and so help to focus the search for the genetic component. Understanding genetic factors underlying disease susceptibility is vitally important to inform genetic counselling. In addition, understanding the various factors which lead to IBD is critical to developing rational treatments which target cause rather than the symptoms of the disease.

炎症性肠病（IBD）有两种临床形式，称为溃疡性结肠炎（UC）和克罗恩病（CD）。这些严重疾病主要影响年轻人。它们有时是致命的，而且往往严重衰弱。UC的治疗通常需要切除大肠和终身佩戴回肠造口袋。虽然这是有疗效的，但其心理和生活方式的影响非常令人不安，特别是在年轻人中。IBD的原因尚不清楚，但很明显有遗传和环境因素。我们已经在小鼠中开发了IBD模型，其看起来非常像人类UC。我们已经培育出了转基因小鼠，它们的肠壁分泌的粘液似乎与正常小鼠不同。我们建议调查这种变化如何导致UC。它似乎可能是有缺陷的粘液，不能阻止一些正常的细菌或其他材料存在于粪便进入肠壁，并引起慢性炎症。如果我们能够证明这是事实，它将有力地支持这样一种观点，即类似的遗传特征可能发生在某些人身上，这可能是使他们容易患IBD的遗传成分之一。换句话说，这将是一个指针，指出可能导致人类易感性的遗传缺陷类型，从而有助于集中精力寻找遗传成分。了解疾病易感性的遗传因素对遗传咨询至关重要。此外，了解导致IBD的各种因素对于开发针对病因而不是疾病症状的合理治疗至关重要。