A novel CD39-like ecto-NTPDase of Legionella pneumophila

嗜肺军团菌的新型 CD39 样胞外 NTPD 酶

• 批准号: nhmrc : 436607
• 负责人: Prof Anthony D'Apice
• 金额: $ 24.14万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-cd39-like-legionella-pneumophila/82768
• 关键词: novel; CD39; like; ecto; NTPDase

Legionnaire's disease is a serious cause of community acquired pneumonia. We are studying the way the Legionella bacteria persist in the environment and cause disease. We have found that Legionella produces a specific protein that mimics the action of a human protein. This proposal aims to work out how the bacteria use this protein to infect the human lung and escape killing by immune cells. The results from this study will help to determine if this protein may be used as a target for the development of new anti-infective drugs.

军团病是社区获得性肺炎的一个严重原因。我们正在研究军团菌如何在环境中持续存在并导致疾病。我们发现军团菌产生一种特殊的蛋白质，它模仿人类蛋白质的作用。这项提议旨在研究细菌如何利用这种蛋白质感染人类肺部，并逃脱免疫细胞的杀死。这项研究的结果将有助于确定该蛋白是否可以用作开发新的抗感染药物的靶标。