Application of adult stem cells to bioengineered corneal epithelium and endothelium autografts

成体干细胞在生物工程自体角膜上皮和内皮移植中的应用

• 批准号: nhmrc : 1017521
• 负责人: Dr Karl Brown
• 金额: $ 6.16万
• 依托单位: Centre for Eye Research Australia Ltd
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/application-adult-stem-endothelium-autografts/109873
• 关键词: Application; adult; stem; cells; bioengineered

Damage to the cornea causes vision loss. Transplants can restore sight but carry risk of rejection and therefore require anti-rejection therapy, which has side effects. Bioengineered corneal components could replace transplants. Our goals are: 1) Growth of corneal endothelium and epithelium from adult stem cells to reduce the amount of tissue so the patient's own cells could be used. 2) Develop scaffolds that are suitable for implantation or other methods to deliver cells.

角膜损伤会导致视力丧失。移植可以恢复视力，但存在排斥风险，因此需要抗排斥治疗，但这种治疗有副作用。生物工程角膜组件可以取代移植物。我们的目标是： 1) 利用成体干细胞生长角膜内皮和上皮，以减少组织数量，以便可以使用患者自身的细胞。 2）开发适合植入或其他方法输送细胞的支架。