Applying quantitative immunology to the analysis of complex genetic diseases

将定量免疫学应用于复杂遗传疾病的分析

• 批准号: nhmrc : 1127198
• 负责人: Dr Edwin Hawkins
• 金额: $ 59.07万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/applying-quantitative-immunology-genetic-diseases/947962
• 关键词: Applying; quantitative; immunology; analysis; complex

The immune response of each individual varies. For some, the response invoked by foreign challenge is weak, leading to a lifetime of difficulty with infection. For others, the response is stronger, yielding excellent immunity, but opening the potential for overactive responses to self-material and autoimmune disease. We have a new theory for how the health of our immune system can be measured and we aim to apply it to understand the genesis of the many different forms of human immune diseases.

每个人的免疫反应各不相同。对于一些人来说，对外来挑战引起的反应很弱，导致终生难以感染。对于其他人来说，反应更强烈，产生良好的免疫力，但也有可能对自身物质和自身免疫性疾病做出过度活跃的反应。我们有一个关于如何测量免疫系统健康状况的新理论，我们的目标是应用它来了解许多不同形式的人类免疫疾病的起源。