In vivo imaging of protective and malignant B cell function

保护性和恶性 B 细胞功能的体内成像

• 批准号: nhmrc : 1086977
• 负责人: Dr Edwin Hawkins
• 金额: $ 28.77万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vivo-imaging-protective-cell-function/519157
• 关键词: vivo; imaging; protective; malignant; cell

B cells are responsible for producing antibody that protects us from infection. Disruption of healthy B cell function can lead to a myriad of diseases including immunodeficiency, autoimmunity and blood cancers such as leukaemia. The aim of my work is to use powerful microscopy to visualise how mutated B cells interact with their surrounding environment in real-time. These studies will allow the development of new treatments for cancer and immune conditions that target these interactions.

B细胞负责产生抗体，保护我们免受感染。健康的B细胞功能障碍会导致无数疾病，包括免疫缺陷、自身免疫和白血病等血癌。我工作的目的是使用强大的显微镜来实时可视化突变的B细胞如何与周围环境相互作用。这些研究将允许开发针对这些相互作用的癌症和免疫状况的新疗法。