The molecular basis to the development and function of the thymic microenvironment.

胸腺微环境发育和功能的分子基础。

• 批准号: nhmrc : 143682
• 负责人: A/Pr Ann Chidgey
• 金额: $ 15.14万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-development-thymic-microenvironment/100900
• 关键词: molecular; basis; development; function; thymic

The ability of the body to defend itself against infection is dependent on white cells in the blood called T lymphocytes, so-named because they are produced in the thymus gland. In the absence of these T cells, there is severe immunodeficiency. On other hand if the T cells are hyperactive, they can confuse their role and destroy normal tissues (autoimmunity). Imbalances in the types of T cells can also predispose patients to allergies and failures in responses to tumours. This project seeks to identify the genes required to create T cells in the thymus. Specifically it addresses the structural cells of the thymus which provide the unique environment for converting bone marrow precursors exclusively into T lymphocytes. Understanding the genetic and thus molecular basis to this will be very important biologically but may also provide more sophisticated stratgies for treating diseases on T cell origin.

身体抵御感染的能力依赖于血液中被称为T淋巴细胞的白色细胞，之所以这样命名是因为它们是在胸腺中产生的。在缺乏这些T细胞的情况下，存在严重的免疫缺陷。另一方面，如果T细胞过度活跃，它们可能会混淆它们的作用并破坏正常组织（自身免疫）。T细胞类型的不平衡也会使患者易患过敏症和对肿瘤的反应失败。该项目旨在确定在胸腺中产生T细胞所需的基因。具体而言，它涉及胸腺的结构细胞，其提供将骨髓前体专门转化为T淋巴细胞的独特环境。了解其遗传和分子基础在生物学上将非常重要，但也可能为治疗T细胞起源的疾病提供更复杂的策略。