All in the family: understanding a new class of bacterial toxins
All in the family: understanding a new class of bacterial toxins
批准号:
DP230101148
负责人:
Prof Michael Parker
金额:
$47.45万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2023
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2023-01-01 至 2025-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This project aims to unravel missing molecular details of how a major superfamily of proteins is able to drill holes in cell membranes. Animals, plants, fungi and bacteria all use pore-forming proteins as cell-killing weapons of mass destruction. Despite their lethal nature and their roles in infection and immunity, how these proteins work remains enigmatic. The outcomes could reveal novel mechanisms general to these proteins and provide fundamental insights in understanding vital physiological processes across all kingdoms of life. Ultimately, this knowledge may guide the design of artificial protein pores that are selective for specific molecules with applications such as measuring metal ions, sugars, pesticides or pollutants.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
How do signals cross the cell membrane: the betacommon receptor family
-
批准号:DP220101788
-
项目类别:Discovery Projects
-
资助金额:$43.24万
-
财政年份:2022
-
负责人:Prof Michael Parker
-
依托单位:
Hydrogen-deuterium exchange system - a missing link in protein analysis
-
批准号:LE210100122
-
项目类别:Linkage Infrastructure, Equipment and Facilities
-
资助金额:$48.34万
-
财政年份:2021
-
负责人:Prof Michael Parker
-
依托单位:
Pore-forming toxins: more than one way to make a hole
-
批准号:DP200102871
-
项目类别:Discovery Projects
-
资助金额:$39.33万
-
财政年份:2020
-
负责人:Prof Michael Parker
-
依托单位:
Understanding cell signalling as a basis for new therapeutics
-
批准号:nhmrc : 1117183
-
项目类别:Research Fellowships
-
资助金额:$59.07万
-
财政年份:2017
-
负责人:Prof Michael Parker
-
依托单位:
A collaborative electron microscopy network for structural biology
-
批准号:LE170100016
-
项目类别:Linkage Infrastructure, Equipment and Facilities
-
资助金额:$56.68万
-
财政年份:2017
-
负责人:Prof Michael Parker
-
依托单位:
Understanding cell signalling as a basis for new therapeutics
-
批准号:nhmrc : GNT1117183
-
项目类别:Research Fellowships
-
资助金额:$86.39万
-
财政年份:2017
-
负责人:Prof Michael Parker
-
依托单位:
Understanding how pore-forming proteins punch holes in membranes
-
批准号:DP160101874
-
项目类别:Discovery Projects
-
资助金额:$43.68万
-
财政年份:2016
-
负责人:Prof Michael Parker
-
依托单位:
Understanding how a family of chloride pumps and channels are regulated
-
批准号:DP150100673
-
项目类别:Discovery Projects
-
资助金额:$51.87万
-
财政年份:2015
-
负责人:Prof Michael Parker
-
依托单位:
Research Fellowship
-
批准号:nhmrc : 1021645
-
项目类别:Research Fellowships
-
资助金额:$55.8万
-
财政年份:2012
-
负责人:Prof Michael Parker
-
依托单位:
H1N1 Swine influenza: Molecular basis of potential resistance to neuraminidase inhibitors
-
批准号:nhmrc : 620240
-
项目类别:NHMRC Strategic Awards
-
资助金额:$6.48万
-
财政年份:2009
-
负责人:Prof Michael Parker
-
依托单位:
Molecular analysis of glutathione transferase interactions with drugs and physiological ligands
-
批准号:DP0770301
-
项目类别:Discovery Projects
-
资助金额:$18.25万
-
财政年份:2008
-
负责人:Prof Michael Parker
-
依托单位:
Avian influenza: Molecular basis of potential resistance to neuraminidase inhibitors
-
批准号:nhmrc : 395533
-
项目类别:NHMRC Strategic Awards
-
资助金额:$5.82万
-
财政年份:2006
-
负责人:Prof Michael Parker
-
依托单位:
Structural neurobiology - developing a new capability in Australia to treat mental illness
-
批准号:FF0669018
-
项目类别:Federation Fellowships
-
资助金额:$110.84万
-
财政年份:2006
-
负责人:Prof Michael Parker
-
依托单位:
Structural studies of bacterial pore-forming protein toxins
-
批准号:nhmrc : 395511
-
项目类别:NHMRC Project Grants
-
资助金额:$33.94万
-
财政年份:2006
-
负责人:Prof Michael Parker
-
依托单位:
Structural studies of glutathione transferases: a model system for functional genomics and drug design
-
批准号:DP0450470
-
项目类别:Discovery Projects
-
资助金额:$22.98万
-
财政年份:2004
-
负责人:Prof Michael Parker
-
依托单位:
Structural studies of amyloid precursor protein
-
批准号:nhmrc : 296201
-
项目类别:NHMRC Project Grants
-
资助金额:$32.11万
-
财政年份:2004
-
负责人:Prof Michael Parker
-
依托单位:
Structural studies of bacterial pore-forming protein toxins
-
批准号:nhmrc : 247911
-
项目类别:NHMRC Project Grants
-
资助金额:$17.85万
-
财政年份:2003
-
负责人:Prof Michael Parker
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 205304
-
项目类别:NHMRC Research Fellowships
-
资助金额:$51.01万
-
财政年份:2002
-
负责人:Prof Michael Parker
-
依托单位:
Xenon gas chamber - Tool for protein Crystallography
-
批准号:nhmrc : 1601
-
项目类别:NHMRC Infrastructure Grants
-
资助金额:$0.07万
-
财政年份:2000
-
负责人:Prof Michael Parker
-
依托单位:
CRYSTAL STRUCTURES OF ION CHANNEL PROTEINS
-
批准号:nhmrc : 124001
-
项目类别:NHMRC Project Grants
-
资助金额:$23.9万
-
财政年份:2000
-
负责人:Prof Michael Parker
-
依托单位:
国内基金
海外基金
Navigating Sustainability: Understanding Environm ent,Social and Governanc e Challenges and Solution s for Chinese Enterprises
in Pakistan's CPEC Framew
ork
-
批准号:--
-
项目类别:外国学者研究基金项目
-
资助金额:--
-
批准年份:2024
-
负责人:Noshaba Aziz
-
依托单位:
Understanding structural evolution of galaxies with machine learning
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:Nicola Rosario Napolitano
-
依托单位:
Understanding complicated gravitational physics by simple two-shell systems
-
批准号:12005059
-
项目类别:青年科学基金项目
-
资助金额:24.0万元
-
批准年份:2020
-
负责人:国分隆文
-
依托单位: