Neural control of colorectal function and identification of sites of drug action

结直肠功能的神经控制和药物作用位点的识别

• 批准号: nhmrc : 1079739
• 负责人: Dr Leni Rivera
• 金额: $ 25.04万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neural-control-colorectal-drug-action/518697
• 关键词: Neural; control; colorectal; function; identification

Constipation is a considerable problem, especially in the elderly; it occurs in 20-25% of people over 65 and in about 50% of people in nursing homes. It is also a significant concern for children, with up to 30% being affected. There are no adequate treatments and the majority of people are dissatisfied with their management. We have discovered a class of compounds that stimulate defecation. In this project we will test the effectiveness of these compounds to relieve constipation.

便秘是一个相当大的问题，特别是在老年人中;它发生在20-25%的65岁以上的人和大约50%的养老院的人中。这也是儿童的一个重大问题，多达30%的儿童受到影响。没有适当的治疗，大多数人对他们的管理不满意。我们发现了一类刺激排便的化合物。在这个项目中，我们将测试这些化合物缓解便秘的有效性。