The precise steps in dendritic cell development

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Dendritic cells (DCs) are the body’s sentinels, with three specialized subtypes. They monitor for infections and cancer and then activate immune T cells to clear it. Interestingly, they can all arise from a single cell, but the precise steps are unknown. By literally filming this process and analyzing the movie, we hope to draw the ‘family trees’ that lead to their generation. This knowledge will offer crucial clues as to how to boost or reduce their numbers for medical applications.